反应详情

To a solution of 6-(2-chlorophenyl)-2-methylthio-pyrido[2,3-d]pyrimidin-7-ol (25.2 g, 82.9 mmol) in 700 mL of tetrahydrofuran was added a slurry of Oxone™ (105 g, 171 mmol) in 200 mL of water. The reaction mixture was stirred for 5 hours, filtered, then concentrated in vacuo. The resulting slurry was filtered and the collected solid was washed with water and dried to give 23.2 g (83%) of 6-(2-chlorophenyl)-2-methanesulfonyl-pyrido[2,3-d]pyrimidin-7-ol (Sulfone 2) as a light-yellow solid. (mass spec. M+H+=336, mp=215.1-221.1° C.).

1. filtrationfiltered
2. concentrationconcentrated in vacuo
3. filtrationThe resulting slurry was filtered
4. washthe collected solid was washed with water
5. customdried