HCID 18677117, compound → HCID 18677134, compound

Participants

Reaction Steps

To a solution of methyl triphenylphosphonium bromide (3.47 g, 9.72 mmol) in THF (20 mL) was added 1 M KOt-Bu in THF (9.73 mL, 9.73 mmol) followed by the above ketone (2.10 g, 8.10 mmol). The mixture was stirred at room temperature for 4 hrs, quenched with water and extracted with ethyl acetate. The extract was dried over Na2SO4 and concentrated. The residue was slurried with hexane and filtered. The filtrate was concentrated to give the title compound as a white solid (1.46 g, 70%). mp: 61-63° C.

Provenance & Evidence