反应详情

To a stirred solution of 2,6-dimethylbenzonitrile (1 g, 7.6 mmol) in THF (15 mL) under argon at 0° C. a solution of DIBAL (1 M in THF, 8 mL, 8 mmol) was added dropwise over 5 minutes. After 3 hr at 0° C., the reaction mixture was brought to room temperature and stirred overnight. The reaction was quenched with 5% sulfuric acid at 0° C., extracted with ether, washed with brine and dried (MgSO4). Concentration provided 2,6-dimethylbenzaldehyde (0.9 g) which was used without further purification.

1. customwas brought to room temperature
2. customThe reaction was quenched with 5% sulfuric acid at 0° C.
3. extractionextracted with ether
4. washwashed with brine
5. dry with materialdried (MgSO4)
6. concentrationConcentration