Potassium Hydroxide → HCID 10892106, compound

Participants

Reaction Steps

A solution of methyl 4-(5,6-dichloro-1H-indol-2-yl)benzoate (0.86 g, 2.7 mmol) and KOH (0.36 g, 6.4 mmol) in a mixture of EtOH (15 ml) and water (15 ml) was refluxed for 3 h. After concentration of the ethanol, the solution was acidified and extracted with ethyl acetate. The organic phase was washed with water, dried over MgSO4 and concentrated in vacuo to afford 0.58 g (1.8 mmol, yield 70%) of the acid used without further purification.

Provenance & Evidence