Potassium Hydroxide → HCID 22675046, compound

Participants

Reaction Steps

Ethyl 3-methoxy-4-(5,6-dichloro-1H-indol-2-yl)-benzoate (1 g, 2.7 mmol) was added to a solution of KOH (0.4 g, 7 mmol) in EtOH (50 ml) and the mixture was refluxed for 4 h. The solvent was concentrated and the residue was dissolved in water. The aqueous solution was acidified with HCl then extracted with AcOEt. The organic phase was washed with water, dried over MgSO4 and concentrated in vacuo yielding 0.89 g (2.6 mmol, yield 99%) of the title compound.

Provenance & Evidence