HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isobutyl Ketone → HCID 86585567, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isobutyl Ketone | HCID 7909 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 8-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole | HCID 3157459 | — |
| Reactant | HCID 21802683 | HCID 21802683 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Product | HCID 86585567 | HCID 86585567 | 80% |
Reaction Steps
A mixture of 2,3,4,5-tetrahydro-8-methyl-1H-pyrido[4,3-b]indole, (0.079 mol), ethyl 3-chloropropanamide (0.097 mol), Na2CO3 (15 g) and potassium iodide (0.1 g) in methyl isobutyl ketone (350 ml) was stirred and refluxed overnight. The reaction mixture was filtered and the filtrate was evaporated, yielding 20 g (80%) of ethyl [3-(1,3,4,5-tetrahydro-8-methyl-2H-pyrido[4,3-b]indol-2-yl)propyl]carbamate (intermediate 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506768B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-a17fe39a68a84fd9bf623dbf4b3b0b1a |
| Source note | uspto-grants-2003_01 |