Potassium Hydroxide → HCID 18677423, compound

Participants

Reaction Steps

A mixture of intermediate (10) (0.063 mol) and KOH (35 g) in 2-propanol (300 ml) was stirred and refluxed overnight. The solvent was evaporated. The residue was stirred in water and this mixture was extracted with methyl isobutyl ketone. The separated organic layer was dried, filtered and the solvent evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/(CH3OH/NH3) 85/15). The pure fractions were collected and the solvent was evaporated, yielding 7 g (46%) of 1,3,4,5-tetrahydro-8-methyl-2H-pyrido[4,3-b]indole-2-propanamine (intermediate 11).

Provenance & Evidence