1,3-Thiazole-2-carbaldehyde → HCID 18677565, compound

HRID 1634218Notes

Reaction equation

HRID 1634218 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])[CH:5]=[C:4]([NH2:17])[N:3]=1.C1(C)C=C(C)C=C(C)C=1S([NH:29]O)(=O)=O.[S:32]1[CH:36]=[CH:35][N:34]=[C:33]1[CH:37]=O>>[NH2:17][C:4]1[N:3]2[N:29]=[C:37]([C:33]3[S:32][CH:36]=[CH:35][N:34]=3)[N:1]=[C:2]2[CH:7]=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])[CH:5]=1

Participants

4

Reactant 3

HCID 27349031,3-Thiazole-2-carbaldehydeHCID 11009332O-mesitylenesulfonylhydroxylamineHCID 18677530HCID 18677530, compound

Product 1

HCID 18677565HCID 18677565, compound

Procedure

The title compound, MS m/e (%): 340 (M+H+, 100), was prepared in accordance with the general method of example 373 from (2,6-diamino-pyridin-4-yl)-(4-fluoro-phenyl)-methanone, o-mesitylene-sulfonylhydroxylamine, and thiazole-2-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-4ea9c64e458247698b6a1539290e5df5
Source dataset
uspto-grants-2003_01
Patent number
US06506772B1

Reaction notes

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