反应详情

4,4,4-Trifluoro-1-(4-bromophenyl)1,3-butanedione (600 mg) (prepared according to the method of Thomas D. Penning, et al.; J. Med. Chem., 1997, 40, 1347-1365.) and 2-hydrazino-5-(methylsulfonyl)pyridine hydrochloride (420 mg) were mixed in ethanol (40 mL), and the resulting solution was refluxed for 3 days. Upon cooling, white precipitates came out. The white precipitates were collected by filtration and purified by flash chromatography using 70:30 of methylene chloride and hexane to give the title compound (450 mg).

1. temperaturethe resulting solution was refluxed for 3 days
2. temperatureUpon cooling
3. customwhite precipitates
4. customThe white precipitates
5. filtrationwere collected by filtration
6. custompurified by flash chromatography