Phenylacetylene → HCID 18677777, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 1-[4-(methylsulfonyl)phenyl]-5-(4-bromophenyl)-3-trifluoromethyl-1H-pyrazole (445 mg; 1 mmol) and phenylacetylene (102 mg; 1 mmol) in pyrrolidine (2 mL) was added tetrakis(triphenylphosphine)palladium (35 mg) under a nitrogen atmosphere, and the mixture was heated at 80° C. for 1 hour. After cooling, the volatiles were removed by evaporation. The residue was purified by flash chromatography (SiO2) eluting with ethyl acetate/hexane (1:3) to give the title compound (0.4 g, 86% yield).

Provenance & Evidence