Hydrochloride methanol → (2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride

HRID 1634331Notes

Reaction equation

HRID 1634331 reaction equation
[F:1][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:25][C:26]([F:29])([F:28])[F:27])=[C:9]([CH:24]=1)[CH2:10][NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][NH:14][C@H:13]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([F:4])[CH3:3].CO.[ClH:32]>>[ClH:32].[ClH:32].[F:4][C:2]([C:5]1[CH:6]=[CH:7][C:8]([O:25][C:26]([F:27])([F:28])[F:29])=[C:9]([CH:24]=1)[CH2:10][NH:11][C@H:12]1[CH2:17][CH2:16][CH2:15][NH:14][C@H:13]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 57090611(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine

Product 1

HCID 86757653(2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochlorideYield 87%

Procedure

The Compound 27 (360 mg. 0.87 mmol)was treated with methanol-hydrogen chloride (ca 20 ml) and the solvent was evaporated in vacuo to give crude product as a white solid. The crude product was recrystallized from ethanol-diethyl ether to give Compound 28 (370 mg, 87%) as a white solid.

Workup

  1. customthe solvent was evaporated in vacuo
  2. customto give crude product as a white solid
  3. customThe crude product was recrystallized from ethanol-diethyl ether

Sources & evidence

ORD record
ord-e3a7bd530e8f4aae879cd5222dabe1be
Source dataset
uspto-grants-2003_01
Patent number
US06506775B1

Reaction notes

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