(2S, 3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidine → (2S,3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidine dihydrochloride

HRID 1634339Notes

Reaction equation

HRID 1634339 reaction equation
[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:20]([C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])=[CH:19][C:4]=1[CH2:5][NH:6][C@H:7]1[CH2:12][CH2:11][CH2:10][NH:9][C@H:8]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[ClH:30].Cl.FC(C1C=CC(OC(F)(F)F)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(F)C>>[ClH:30].[ClH:30].[CH3:1][O:2][C:3]1[CH:22]=[CH:21][C:20]([C:23]([F:29])([F:28])[C:24]([F:25])([F:26])[F:27])=[CH:19][C:4]=1[CH2:5][NH:6][C@H:7]1[CH2:12][CH2:11][CH2:10][NH:9][C@H:8]1[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 57114467(2S, 3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidineHCID 86757653(2S,3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine dihydrochloride

Product 1

HCID 86758790(2S,3S)-3-(2-Methoxy-5-(1,1,2,2,2-pentafluoroethyl)benzyl)amino-2-phenylpiperidine dihydrochloride

Procedure

This compound was prepared from Compound 42 in the same manner of Compound 28.

Sources & evidence

ORD record
ord-b5b223c1d2604129b8067229fec3376c
Source dataset
uspto-grants-2003_01
Patent number
US06506775B1

Reaction notes

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