Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylate → (2S,3S)-1-tert-Butoxycarbonyl-3-[5-(1,1-dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine

HRID 1634343Notes

Reaction equation

HRID 1634343 reaction equation
[CH3:1][C:2]([C:10]1[CH:11]=[CH:12][C:13]([O:18][CH3:19])=[C:14]([CH:17]=1)[CH:15]=O)([CH3:9])[C:3]#[C:4][C:5]([F:8])([F:7])[F:6].[NH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][N:23]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH:22]1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[C:30]([O:29][C:27]([N:23]1[CH2:24][CH2:25][CH2:26][C@H:21]([NH:20][CH2:15][C:14]2[CH:17]=[C:10]([C:2]([CH3:9])([CH3:1])[C:3]#[C:4][C:5]([F:8])([F:7])[F:6])[CH:11]=[CH:12][C:13]=2[O:18][CH3:19])[C@@H:22]1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:28])([CH3:33])([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 10214733Tert-butyl 3-amino-2-phenylpiperidine-1-carboxylateHCID 186776475-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzaldehyde

Product 1

HCID 70001735(2S,3S)-1-tert-Butoxycarbonyl-3-[5-(1,1-dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine

Procedure

This compound was prepared from Compound 58 and Compound 12 in the same manner of Compound 13.

Sources & evidence

ORD record
ord-346c0b7b89e0417690ad24b6af025f24
Source dataset
uspto-grants-2003_01
Patent number
US06506775B1

Reaction notes

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