HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634353Generated: November 3, 2026
Dimethylformamide → 4-(2,2,2-Trifluoro-1-methyl-1-(trifluoromethyl)ethyl)anisole
https://huagongshe.com/reaction/1634353
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | 4-(2,2-Difluoro-1-(trifluoromethyl)ethenyl)anisole | HCID 11776330 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2,2,2-Trifluoro-1-methyl-1-(trifluoromethyl)ethyl)anisole | HCID 18677601 | 10% |
Reaction Steps
A mixture of Compound 74 (570 mg, 2.4 mmol), MeI (430 mg, 3.0 mmol), and CsF (760 mg, 5.0 mmol) in DMF (4 ml) was stirred at 80° C. for 3 days. The mixture was diluted with H2O. The organic layer was separated and the aqueous layer was extracted with CH2Cl2. The combined solution was dried (Na2SO4) and concentrated in vacuo to give crude product, which was purified by column chromatography on silica gel to give Compound 75 (70 mg, 10%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06506775B1 |
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| Source dataset | uspto-grants-2003_01 |
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| ORD ID | ord-665f97d163074b4a8d115c57072eb292 |
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| Source note | uspto-grants-2003_01 |
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