(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S, 3S)-3-[5-[2,2-Difluoro-1-(trifluoromethyl)ethenyl]-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride
Reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([C:26]([F:29])([F:28])[F:27])=[C:23]([F:25])[F:24])[CH:19]=[CH:18][C:17]=2[O:30][CH3:31])[C@@H:9]1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=O)(C)(C)C.[ClH:38].Cl.CC(C1C=CC(OC)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)(C)C#CC(F)(F)F>>[ClH:38].[ClH:38].[F:25][C:23]([F:24])=[C:22]([C:20]1[CH:19]=[CH:18][C:17]([O:30][CH3:31])=[C:16]([CH:21]=1)[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:26]([F:27])([F:29])[F:28]Participants
3
Reactant 2
Product 1
Procedure
This compound was prepared from Compound 80 in the same manner of Compound 60.
Sources & evidence
- ORD record
- ord-37cda91b37b643eeaa2b585a8ff22a65
- Source dataset
- uspto-grants-2003_01
- Patent number
- US06506775B1
Reaction notes
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