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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634363Generated: November 2, 2026

(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidine → (2S,3S)-3-((6-Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine

https://huagongshe.com/reaction/1634363

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S, 3S)-3-(5-(1,1-Difluoroethyl)-2-(trifluoromethoxy)benzyl)amino-2-phenylpiperidineHCID 57090611—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-3-((6-methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidineHCID 70000884—
Product(2S,3S)-3-((6-Methoxy-1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidineHCID 44593634—

Reaction Steps

This compound was prepared from Compound 92 in the same manner of Compound 27.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506775B1
Source datasetuspto-grants-2003_01
ORD IDord-97b4e5e8da2a441dbbc985308441b403
Source noteuspto-grants-2003_01