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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634365Generated: October 30, 2026

(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochloride → (2S,3S)-3-((2,2-Difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochloride

https://huagongshe.com/reaction/1634365

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S,3S)-3-[5-(1,1-Dimethyl-4,4,4-trifluoro-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine dihydrochlorideHCID 70000615—
Reactant(2S,3S)-1-tert-Butoxycarbonyl-3-((2,2-difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidineHCID 70001230—
Product(2S,3S)-3-((2,2-Difluoro-6-methoxy-1,2,3,4-tetrahydronaphthalen-7-yl)methyl)amino-2-phenylpiperidine dihydrochlorideHCID 69999940—

Reaction Steps

This compound was prepared from Compound 97 in the same manner of Compound 60.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506775B1
Source datasetuspto-grants-2003_01
ORD IDord-4957fda31ed04b8caa799cb05879a81d
Source noteuspto-grants-2003_01