HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Difluorophenylacetic acid → (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Difluorophenylacetic acid | HCID 145424 | — |
| Reactant | (s)-2-(1-Aminoethyl)-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723742 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | (s)-2-[1-(3,5-Difluorophenylacetamido)ethyl]-5(r,s)-ethoxycarbonyl-2-oxazoline | HCID 131723741 | — |
Reaction Steps
Following General Procedure A and using 3,5-difluorophenylacetic acid (Aldrich) and (S)-2-(1-aminoethyl)-5(R,S)-ethoxycarbonyl-2-oxazoline (Example F), the title compound was prepared as a semisolid. The reaction was monitored by tlc (Rf=0.3 in 5% MeOH/CHCl3) and the product was purified by silica gel chromatography using 5% MeOH/CHCl3 as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506782B1 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-70c83da38499457b9ec3dc2eaac0e907 |
| Source note | uspto-grants-2003_01 |