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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634480Generated: November 5, 2026

3,5-Difluorophenylacetic acid → N-[(3,5-difluorophenyl)acetyl]alanine iso-butyl ester

https://huagongshe.com/reaction/1634480

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reactant2-methylpropyl (2S)-2-aminopropanoateHCID 13743556—
ProductN-[(3,5-difluorophenyl)acetyl]alanine iso-butyl esterHCID 22894975—

Reaction Steps

Following General Procedure BI above, and using 3,5-difluorophenylacetic acid (Aldrich) and alanine iso-butyl ester (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506782B1
Source datasetuspto-grants-2003_01
ORD IDord-03223bcaf3bd4e0c81b30c3b155d15d5
Source noteuspto-grants-2003_01