Triethylamine → HCID 11004632, compound

Participants

Reaction Steps

Ethyl 3-(3-carboxy-4-methoxyphenyl)-2-ethylpropanoate (5.00 g, 17.8 mmol) was dissolved in 80 ml of dehydrated dichloroethane, which was cooled to −10° C. to −15° C. Triethylamine (6.21 ml, 44.5 mmol) was added under stirring. Next, ethyl chlorocarbonate (1.86 ml, 19.5 mmol), dissolved in 10 ml of dehydrated dichloromethane was added dropwise. After stirring for 10 minutes at −10° C., 4-(trifluoromethyl)benzylamine (2.51 ml, 17.8 mmol), dissolved in 10 ml of dehydrated dichloromethane was added dropwise.

Provenance & Evidence