Sodium Hydroxide → HCID 9822766, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 2-ethyl-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propanoate (1.26 g, 2.88 mmol; Example 7), 15 ml of ethanol and 15 ml of 1 mol/l aqueous solution of sodium hydroxide were mixed and, after stirring for 4 hours at 50° C., the reaction mixture was concentrated under reduced pressure. The residue was dissolved in water, which was made acidic with dilute hydrochloric acid. The precipitates produced were filtered, dried and then recrystallized from ethyl acetate to obtain 1.26 g (95%) of the title compound as colorless prisms. Melting point 144.5-146.5° C.; Mass analysis m/z 409(M+); Elemental analysis C21H22F3NO4(409.40):

Provenance & Evidence