Ethanol → Ethyl 2-methoxy-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]propanoate

Participants

Reaction Steps

Ethyl 2-methoxy-3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]acrylate (150 mg, 0.354 mmol), 2.5 ml of ethanol and 2.5 ml of tetrahydrofuran were mixed, 10% palladium on activated carbon (30 mg) was added thereto, and normal pressure hydrogenation was conducted for 7.5 hours at room temperature. After completion of the reaction, the catalyst was filtered and the filtrate was concentrated to obtain 148 mg (98%) of the title compound as colorless crystals.

Provenance & Evidence