Methyl 3-(3-benzyloxycarbonyl-4-methoxyphenyl)-2,2-dimethylpropanoate → Methyl 3-(3-carboxy-4-methoxyphenyl)-2,2-dimethylpropanoate

Participants

Reaction Steps

Methyl 3-(3-benzyloxycarbonyl-4-methoxyphenyl)-2,2-dimethylpropanoate (310 mg, 0.870 mmol) was dissolved in 7 ml of mixed solvent of ethanol with tetrahydrofuran at a ratio of 1:1, 10% palladium on activated carbon (20 mg) was added thereto, and normal pressure hydrogenation was conducted for 5 hours. After completion of the reaction, catalyst was filtered and the filtrate was concentrated to obtain 290 mg (90%) of the title compound as a colorless oil.

Provenance & Evidence