Sodium Hydroxide → 3-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-2,2-dimethyl-propionic acid

HRID 1634527Notes

Reaction equation

HRID 1634527 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([CH3:16])([CH3:15])[C:11]([O:13]C)=[O:12])=[CH:5][C:4]=1[C:17](=[O:30])[NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=1.[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([CH3:16])([CH3:15])[C:11]([OH:13])=[O:12])=[CH:5][C:4]=1[C:17](=[O:30])[NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18678023Methyl 3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]-2,2-dimethylpropanoate

Product 1

HCID 98443733-[4-Methoxy-3-(4-trifluoromethyl-benzylcarbamoyl)-phenyl]-2,2-dimethyl-propionic acidYield 90%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using methyl 3-[4-methoxy-3-[N-[[4-(trifluoromethyl)phenyl]methyl]carbamoyl]phenyl]-2,2-dimethylpropanoate (300 mg, 0.708 mmol; Example 47), ethanol (5 ml) and 10% aqueous solution of sodium hydroxide (2 ml) and conducting the procedure similar to Example 22, 206 mg (90%) of the title compound were obtained as colorless crystals.

Sources & evidence

ORD record
ord-bc6088fa0d55447dad8f397d560e86cd
Source dataset
uspto-grants-2003_01
Patent number
US06506797B1

Reaction notes

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