Benzylamine → HCID 178428437, compound

HRID 1634552Notes

Reaction equation

HRID 1634552 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([OH:9])[C:3]=1[N+:10]([O-:12])=[O:11].[CH2:13]([NH2:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CCO>[CH2:13]([NH:20][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([OH:9])[C:3]=1[N+:10]([O-:12])=[O:11])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 178426130HCID 178426130, compound

Product 1

HCID 178428437HCID 178428437, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Stir a solution of 4-chloro-6-methyl-3-nitro-pyridin-2-ol (10.0 g, 53.0 mmol) and benzyl amine (17.3 g, 159 mmol) in EtOH (30 mL) at ambient temperature for 12 h, then concentrate in vacuo. Pour the resulting residue into water, acidify to pH 3 with 1N HCl and filter. Wash the precipitate several times with water to obtain the title compound as a yellow solid.

Workup

  1. concentrationconcentrate in vacuo
  2. additionPour the resulting residue into water
  3. filtrationfilter
  4. washWash the precipitate several times with water

Sources & evidence

ORD record
ord-17bb2617dd2e421b8501351f96677c9b
Source dataset
uspto-grants-2003_01
Patent number
US06506762B1

Reaction notes

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