HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one → 2-(1-methoxypropyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 11747336 | — |
| Reactant | 3-(Benzyloxy)-2-(1-hydroxypropyl)-6-methyl-4H-pyran-4-one | HCID 18678826 | — |
| Product | 2-(1-methoxypropyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 18678800 | 90.3% |
Reaction Steps
In an analogous procedure in the preparation of 2-methoxymethyl-3-benzyloxy-6-methyl-pyran-4(1H)-one using 2-(1-hydroxypropyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one (5.48 g, 20 mmol, 1 eq.) yielded the title compound (5.2 g, 90.3%) as an orange oil which solidified on cooling. Recrystallisation from CH2Cl2/Pet. ether 40/60 afforded the pure product as a white crystalline solid. m.p. 63-65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506911B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-a459e845e96a48cb81170022509257b1 |
| Source note | uspto-grants-2003_01 |