Ethylamine → 1-Ethyl-2-methoxymethyl-3-benzyloxy-6-methyl-pyridin-4(1H)-one hydrochloride
Reaction equation
[ClH:1].C[N:3]1C(C)=C(C)C(=O)[C:5](OCC2C=CC=CC=2)=[C:4]1OC.[CH3:22][O:23][CH2:24][C:25]1O[C:27]([CH3:40])=[CH:28][C:29](=[O:39])[C:30]=1[O:31][CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C(N)C>>[ClH:1].[CH2:4]([N:3]1[C:27]([CH3:40])=[CH:28][C:29](=[O:39])[C:30]([O:31][CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)=[C:25]1[CH2:24][O:23][CH3:22])[CH3:5]Participants
4
Procedure
The title compound was prepared by the method outlined for 1,6-dimethyl-2-methoxy-methyl-3-benyloxy-pyridin-4(1H)-one hydrochloride, using 6.5 g (25 mmol, 1 eq.) of 2(1-methoxymethyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one and 4.82 g (75 mmol, 3 eq.) of 70% aqueous ethylamine to yield the pure product 3.7 g (45.7%) after recrystallisation from methanol/diethyl ether, as a white crystalline solid m.p. 114-116° C.
Sources & evidence
- ORD record
- ord-9ee36ba3c1e947d6880c17b9d19b4214
- Source dataset
- uspto-grants-2003_01
- Patent number
- US06506911B2
Reaction notes
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