HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 1,6-Dimethyl-2-(1-ethoxymethyl)-3-benzyloxy-pyridin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1-Ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one | HCID 18678807 | — |
| Reactant | 2-(1-ethoxymethyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one | HCID 18678820 | — |
| Product | 1,6-Dimethyl-2-(1-ethoxymethyl)-3-benzyloxy-pyridin-4(1H)-one | HCID 18678828 | 61.1% |
Reaction Steps
In an analogous procedure in the preparation of 1-ethyl-2-methoxymethyl-3-benzyloxy-pyridin-4(1H)-one using 2-(1-ethoxymethyl)-3-benzyloxy-6-methyl-pyran-4(1H)-one 5.76 g (20 mmol, 1 eq.) and 4.65 g (60 mmol, 3 eq.) of 40% aqueous methylamine yielded the title compound (3.68 g, 61.1%) after purification by column chromatography on silica gel (eluant: 15% CH3OH/85% CHCl3) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506911B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-e2507e1fd0e947e9a0608cd71b7c0d2b |
| Source note | uspto-grants-2003_01 |