反应详情

温度

25 °C

Sodium thiomethoxide (366 g of a 21% aqueous solution, 1.1M) was added during 3 hours to a solution of 2-nitro-4-trifluoromethylbenzonitrile (220.5 g, 1.0M) in acetone (340 g) with stirring at 20-30° C. Stirring was continued for a further 1 hour and the two liquid phases separated. The upper layer (a solution of the product in acetone) was kept at 20° C. when 2-methylthio-4-trifluoromethylbenzonitrile crystallised (213 g), m.p.82° C. The yield was 97%, with product purity >96%.

1. stirringStirring
2. customthe two liquid phases separated
3. customwas kept at 20° C.
4. customcrystallised (213 g), m.p.82° C