Isopropylamine → HCID 18678953, compound

HRID 1634630Notes

Reaction equation

HRID 1634630 reaction equation
C[O:2][C:3](=O)[CH2:4][CH2:5][N:6]([CH3:8])[CH3:7].[CH:10]([NH2:13])([CH3:12])[CH3:11].C[O-].[Na+]>>[CH3:7][N:6]([CH3:8])[CH2:5][CH2:4][C:3]([NH:13][CH:10]([CH3:12])[CH3:11])=[O:2]

Participants

4

Reactant 3

HCID 6363IsopropylamineHCID 199226beta-Alanine, N,N-dimethyl-, methyl esterHCID 10942334Sodium Methoxide

Product 1

HCID 18678953HCID 18678953, compoundYield 98.1%

Procedure

Methyl-3-dimethylaminopropionate (131 g) is stirred as isopropylamine (71 g) as added followed by 30% methanolic sodium methoxide solution (18 g). After 3 days at ambient temperature, GC analysis indicated 98% conversion. Excess isopropylamine is evaporated off under reduced pressure leaving 3-dimethylamino-N-isopropylpropanamide (155 g) as a pale yellow oil.

Workup

  1. additionas added
  2. customExcess isopropylamine is evaporated off under reduced pressure

Sources & evidence

ORD record
ord-f708e7d008c54490a20224bd5e8287ca
Source dataset
uspto-grants-2003_01
Patent number
US06506939B1

Reaction notes

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