化工社化工社 化学情報印刷レポート · 研究参考用
N-Benzoyl-L-asparagine → (2S)-6-[[(2S)-4-amino-2-benzamido-4-oxo-butanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-Benzoyl-L-asparagine | HCID 7062826 | — |
| 反応物 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-L-lysine | HCID 23552860 | — |
| 生成物 | (2S)-6-[[(2S)-4-amino-2-benzamido-4-oxo-butanoyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508586 | — |
反応手順
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-L-lysine (100 mg, 0.29 mmol, example 1, step E) as described in general procedure Bc using Nα-benzoyl-L-asparagine (70 mg, 0.3 mmol) which was prepared in step A this example. The final product was purified by preparative HPLC to yield 14 mg (9%) of the desired material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06506786B2 |
| 出典データセット | uspto-grants-2003_01 |
| ORD ID | ord-282324446470419ba659dcbb9e7062ce |
| 出典メモ | uspto-grants-2003_01 |