HCID 69348744, compound → HCID 508673, compound

HRID 1634688Notes

Reaction equation

HRID 1634688 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C@H:4]([CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])[N:5]([CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)(=[O:8])=[O:7].[C:29]([O:33][C:34]([NH:36][C@H:37]([C:48](O)=[O:49])[CH2:38][C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)[NH:41][CH:40]=1)=[O:35])([CH3:32])([CH3:31])[CH3:30].ON1C(=O)CCC1=O>>[CH3:32][C:29]([O:33][C:34]([NH:36][C@H:37]([C:48]([NH:27][CH2:26][CH2:25][CH2:24][CH2:23][C@H:4]([N:5]([S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][CH:10]=1)(=[O:7])=[O:8])[CH2:17][CH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)[C:3]([O:2][CH3:1])=[O:28])=[O:49])[CH2:38][C:39]1[C:47]2[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=2)[NH:41][CH:40]=1)=[O:35])([CH3:30])[CH3:31]

Participants

3

Reactant 2

HCID 69348744HCID 69348744, compoundHCID 131723745HCID 131723745, compound

Product 1

HCID 508673HCID 508673, compound

Procedure

The title compound was prepared in the same manner as in example 65 (step D) using Nα-cyclopentylmethyl-Nα-(4-methoxybenzenesulfonyl)-L-lysine methyl ester (this example, step B) and Nα-tert-butoxycarbonyl-L-tryptophan-N-hydroxysuccinimide as the starting materials. The yield of the two last reactions was 82%.

Sources & evidence

ORD record
ord-4675b3766d55440b811ce33bf3aa1cba
Source dataset
uspto-grants-2003_01
Patent number
US06506786B2

Reaction notes

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