Hydroxylamine → HCID 18678884, compound

Participants

Reaction Steps

Freshly prepared NH2OH solution (1 M in methanol) (0.2 mL, 0.2 mmol) was added to ethyl 3-[(4-chlorobenzyl)-(4-methoxybenzenesulfonyl)-amino]-propionate (44 mg, 0.1 mmol). After being stirred at room temperature for 18 h, the reaction mixture was concentrated. The crude product was triturated in ether and the residue was lyophilized from water to give N-hydroxy-3-[(4-chlorobenzyl)-(4-methoxybenzene-sulfonyl)-amino]-propionamide (30 mg, 0.08 mmol) as a light yellow solid. 1H-NMR (360 MHz, DMSO-d6) δ 7.75 (d, J=8.8 Hz, 2H), 7.39 (d, J=8.5 Hz, 2H), 7.32 (d, J=8.4 Hz, 2H), 7.11 (d, J=8.8 Hz, 2H), 4.28 (s, 2H), 3.85 (s, 3H), 3.20 (br t, J=7.8 Hz, 2H), 1.86 (t, J=8.1 Hz, 2H).

Provenance & Evidence