Imidazole → HCID 85805408, compound

Participants

Reaction Steps

To a solution of imidazole (4.28 g, 62.89 mmol) and 2-chloro-4-hydroxybenzaldehyde (8.95 g, 57.16 mmol) in CH2Cl2 (500 ml)was added dropwise a solution of t-butyldiphenylchlorosilane (17.27 g, 62.86 mmol) in CH2Cl2, (200 mL). The solution was stirred overnight at ambient temperature. The mixture was then poured into H2O (500 mL) and the organic layer washed with NaHCO3, H2O, brine, and dried (MgSO4). The solvent was removed in vacuo to provide 24.2 g of the title compound.

Provenance & Evidence