Aluminium lithium hydride → (1-Isopropylpiperidin-4-yl)methanamine

HRID 1634750Notes

Reaction equation

HRID 1634750 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([NH2:12])=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:12][CH2:10][CH:7]1[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 223944381-Isopropylpiperidine-4-carboxamide

Product 1

HCID 7258859(1-Isopropylpiperidin-4-yl)methanamineYield 76.2%

Procedure

Prepared from 1-isopropylpiperidine-4-carboxamide (2.5 g, 14.7 mmol) and LAH (1.12 g, 29.4 mmol) according to general the procedure used for Example 8 (Step B) to give 1.75 g of title compound as an oil.

Sources & evidence

ORD record
ord-c36511e6c8364156b2229f810aea1e89
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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