(2S)-2-{[4-(benzyloxy)phenoxy]methyl}oxirane → HCID 10115880, compound

HRID 1634755Notes

Reaction equation

HRID 1634755 reaction equation
[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][C@@H:15]2[CH2:17][O:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][CH2:21][CH:22]1[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]([F:33])([F:32])[F:31])[CH2:24][CH2:23]1>>[CH2:1]([O:8][C:9]1[CH:19]=[CH:18][C:12]([O:13][CH2:14][C@@H:15]([OH:16])[CH2:17][NH:20][CH2:21][CH:22]2[CH2:27][CH2:26][N:25]([CH2:28][CH2:29][C:30]([F:33])([F:31])[F:32])[CH2:24][CH2:23]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11817709(2S)-2-{[4-(benzyloxy)phenoxy]methyl}oxiraneHCID 18678579HCID 18678579, compound

Product 1

HCID 10115880HCID 10115880, compoundYield 3.8%

Procedure

Prepared from 2-(S)-(4-benzyloxy-phenoxymethyl)-oxirane (0.40 g, 1.57 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.329 g, 1.57 mmol) according to the procedure used for Example 2 to provide 0.0280 g of product as a white solid.

Sources & evidence

ORD record
ord-6e67e400c4874ab581187af2a6d9db56
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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