Ammonium formate → HCID 59032971, compound

Participants

Reaction Steps

A mixture of (2S)-1-(4-Benzyloxy-phenoxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol (0.20 g, 0.43 mmol) and ammonium formate (0.135 g, 2.15 mmol) in 10 mL of methanol over 0.20 g of 10% palladium on carbon was stirred at ambient temperature for 2 hours. The catalyst was filtered (solka floc) and the filtrate concentrated in vacuo. Crystallization of the crude oil form EtOAc-hexane provided 0.040 g of the title compound as a white solid.

Provenance & Evidence