HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18678579, compound → 4-((2S)-2-Hydroxy-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propoxy)-9H-carbazol-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18678579 | HCID 18678579 | — |
| Reactant | 3-hydroxy-4-[(2S)-oxiranylmethoxy]-9H-carbazole | HCID 59032948 | — |
| Product | 4-((2S)-2-Hydroxy-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propoxy)-9H-carbazol-3-ol | HCID 10205158 | 16.6% |
Reaction Steps
Prepared from 3-hydroxy-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.260 g, 1.09 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.229 g, 1.09 mmol) according to the procedure used for Example 2 without heating to give 0.084 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-4aa518f311514ee78e715e16108b04b3 |
| Source note | uspto-grants-2003_01 |