HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18678579, compound → (2S)-1-(1-Chloro-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18678579 | HCID 18678579 | — |
| Reactant | 1-Chloro-4-[(2S)-oxiranylmethoxy]-9H-carbazole | HCID 59032946 | — |
| Product | (2S)-1-(1-Chloro-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol | HCID 10206272 | 53.3% |
Reaction Steps
Prepared from 1-chloro-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.085 g, 0.31 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.10 g, 0.48 mmol) according to the procedure used for Example 2 without heating to give 0.080 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-060d7439711747f7af30a875ba159b07 |
| Source note | uspto-grants-2003_01 |