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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1634760Generated: October 30, 2026

HCID 18678579, compound → (2S)-1-(1-Chloro-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol

https://huagongshe.com/reaction/1634760

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 18678579HCID 18678579—
Reactant1-Chloro-4-[(2S)-oxiranylmethoxy]-9H-carbazoleHCID 59032946—
Product(2S)-1-(1-Chloro-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-olHCID 1020627253.3%

Reaction Steps

Prepared from 1-chloro-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.085 g, 0.31 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.10 g, 0.48 mmol) according to the procedure used for Example 2 without heating to give 0.080 g of the title compound as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06506901B2
Source datasetuspto-grants-2003_01
ORD IDord-060d7439711747f7af30a875ba159b07
Source noteuspto-grants-2003_01