HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18678579, compound → (2S)-1-(3-Bromo-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18678579 | HCID 18678579 | — |
| Reactant | 3-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole | HCID 59032961 | — |
| Product | (2S)-1-(3-Bromo-9H-carbazol-4-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol | HCID 10143084 | 61.9% |
Reaction Steps
Prepared from 3-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.083 g, 0.26 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.10 g, 0.48 mmol) according to the procedure used for Example 2 without heating to give 0.085 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-5bca7852a9144d30a7046c068f2f90dd |
| Source note | uspto-grants-2003_01 |