HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18678579, compound → (2S)-1-(1H-Indol-5-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18678579 | HCID 18678579 | — |
| Reactant | (2S)-1-(1H-indol-5-yloxy)-2,3-epoxypropane | HCID 23553465 | — |
| Product | (2S)-1-(1H-Indol-5-yloxy)-3-{[1-(3,3,3-trifluoro-propyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol | HCID 59032943 | 55.1% |
Reaction Steps
Prepared from 5-[(2S)-oxiranylmethoxy]-1H-indole (0.050 g, 0.25 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.105 g, 0.5 mmol) according to the procedure used for Example 2 to give 0.055 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-f16f761896e2427cb4054770b857f59f |
| Source note | uspto-grants-2003_01 |