HCID 18678579, compound → HCID 10158840, compound

HRID 1634764Notes

Reaction equation

HRID 1634764 reaction equation
[O:1]1[CH2:3][C@H:2]1[CH2:4][O:5][C:6]1[C:14]2[C:10](=[N:11][C:12](=[O:15])[N:13]=2)[CH:9]=[CH:8][CH:7]=1.[NH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]([F:29])([F:28])[F:27])[CH2:20][CH2:19]1>>[OH:1][C@@H:2]([CH2:3][NH:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]([F:29])([F:27])[F:28])[CH2:20][CH2:19]1)[CH2:4][O:5][C:6]1[C:14]2[NH:13][C:12](=[O:15])[NH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 18678579HCID 18678579, compoundHCID 86584784HCID 86584784, compound

Product 1

HCID 10158840HCID 10158840, compoundYield 31.6%

Procedure

Prepared from 4-[(2S)-oxiranylmethoxy]-benzimidazol-2-one (0.080 g, 0.38 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0.250 g, 1.2 mmol) of according to the procedure used for Example 2 to give 0.050 g of the title compound as an off-white solid.

Sources & evidence

ORD record
ord-bdbc8230074b43bfbc6118ad3658d220
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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