HCID 18678579, compound → HCID 10201811, compound

HRID 1634765Notes

Reaction equation

HRID 1634765 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([O:11][CH2:12][C@@H:13]1[CH2:15][O:14]1)[CH:7]=[CH:6][CH:5]=2.[NH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]([F:29])([F:28])[F:27])[CH2:20][CH2:19]1>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([O:11][CH2:12][C@@H:13]([OH:14])[CH2:15][NH:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][C:26]([F:29])([F:27])[F:28])[CH2:20][CH2:19]1)[CH:7]=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 18678579HCID 18678579, compoundHCID 59032962(S)-2-Methyl-4-oxiranylmethoxy-1H-indole

Product 1

HCID 10201811HCID 10201811, compoundYield 36%

Procedure

Prepared from 2-methyl-4-[(2S)-oxiranylmethoxy]-indole (0.150 g, 0.74 mmol) and 4-aminomethyl-1-(3,3,3-trifluoropropyl)-piperidine (0. 250 g, 1.2 mmol) of according to the procedure used for Example 2 to give 0.110 g of the title compound as a light yellow solid.

Sources & evidence

ORD record
ord-eceb50adccc14d41b8c5ddb174079aa1
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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