HCID 5105500, compound → HCID 18678430, compound

HRID 1634773Notes

Reaction equation

HRID 1634773 reaction equation
[CH2:1]([N:7]1[CH2:12][CH2:11][CH:10]([C:13]([NH2:15])=O)[CH2:9][CH2:8]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:15][CH2:13][CH:10]1[CH2:11][CH2:12][N:7]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 5105500HCID 5105500, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18678430HCID 18678430, compoundYield 74.8%

Procedure

Prepared from 1-hexylpiperidine-4-carboxamide (6.6 g, 31.0 mmol) and LAH (1.93 g, 62.0 mmol) according to general the procedure used for Example 8 (Step B) to give 4.6 g of title compound as a waxy solid.

Sources & evidence

ORD record
ord-8c3b08d542434a8ebc1ae5d4134e78ee
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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