HCID 18678498, compound → HCID 18678504, compound

HRID 1634784Notes

Reaction equation

HRID 1634784 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[CH2:19][CH2:18][CH:17]([C:20]([NH2:22])=O)[CH2:16][CH2:15]1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[NH2:22][CH2:20][CH:17]1[CH2:16][CH2:15][N:14]([CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1])[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 18678498HCID 18678498, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 18678504HCID 18678504, compoundYield 98%

Procedure

Prepared from 1-(12-hydroxydodecyl)-piperidine-4-carboxamide (3.3 g, 10.6 mmol) and LAH (0.8 g, 21.2 mmol) according to general procedure used for Example 8 (Step B) to give 3.1 g of title compound as a white solid.

Sources & evidence

ORD record
ord-5c06f8f9714a40eebe598e37aa5a8a51
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

Loading…