HCID 18678703, compound → 1-(1-Bromo-9H-carbazol-4-yloxy)-3-{[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylmethyl]-amino}-propan-2-ol

HRID 1634789Notes

Reaction equation

HRID 1634789 reaction equation
[Br:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[C:5]([O:15][CH2:16][C@@H:17]2[CH2:19][O:18]2)=[CH:4][CH:3]=1.NCC1CCN([C:28]2[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:29]=2[S:36]([NH2:39])(=[O:38])=[O:37])CC1>>[Br:1][C:2]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:6]=2[C:5]([O:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:13][CH2:12][CH:7]2[CH2:8][CH2:9][N:39]([S:36]([C:29]3[CH:28]=[CH:33][C:32]([O:34][CH3:35])=[CH:31][CH:30]=3)(=[O:37])=[O:38])[CH2:5][CH2:6]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18678703HCID 18678703, compoundHCID 590329641-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole

Product 1

HCID 235534701-(1-Bromo-9H-carbazol-4-yloxy)-3-{[1-(4-methoxy-benzenesulfonyl)-piperidin-4-ylmethyl]-amino}-propan-2-olYield 77.4%

Procedure

Prepared from 1-bromo-4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.050 g, 0.15 mmol) and (4-aminomethyl-1-piperidinyl) 4-methoxybenzenesulfonamide (0.085 g, 0.3 mmol) of according to procedure used for Example 2 to give 0.035 g of the title compound as a white solid.

Sources & evidence

ORD record
ord-b26db4f48bcb458c8e2215958d23e414
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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