HCID 18678748, compound → HCID 10186287, compound

HRID 1634791Notes

Reaction equation

HRID 1634791 reaction equation
[O:1]1[CH2:3][C@H:2]1[CH2:4][O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH2:8][C:9](=[O:15])[NH:10]2.NC[C:18]1([O:36][CH3:37])[CH:23]=[CH:22][C:21](N2CCCCC2)([S:24]([NH2:27])(=[O:26])=[O:25])[CH:20]=[C:19]1[O:34][CH3:35]>>[CH3:35][O:34][C:19]1[CH:20]=[C:21]([S:24]([N:27]2[CH2:9][CH2:8][CH:7]([CH2:11][NH:10][CH2:3][C@H:2]([OH:1])[CH2:4][O:5][C:6]3[CH:14]=[CH:13][CH:12]=[C:11]4[C:7]=3[CH2:8][C:9](=[O:15])[NH:10]4)[CH2:6][CH2:14]2)(=[O:25])=[O:26])[CH:22]=[CH:23][C:18]=1[O:36][CH3:37]

Participants

3

Reactant 2

HCID 18678748HCID 18678748, compoundHCID 59032953HCID 59032953, compound

Product 1

HCID 10186287HCID 10186287, compoundYield 55.8%

Procedure

Prepared from 4-[(2S)-oxiranylmethoxy]-2-oxindole (0.205 g, 1.0 mmol) and 4-aminomethyl-1-piperidinyl-3,4-dimethoxybenzenesulfonamide (0.628 g, 2.0 mmol) according to procedure used for Example 2 to give 0.145 g of the title compound as a rose colored solid. Dissolved in CH2Cl2 and treated with 0.5 mL of 1N HCl in Et2O. Resulting solids filtered and dried to give 0.140 g of title compound as the HCl salt.

Sources & evidence

ORD record
ord-47b03e0097184781bfea6b1401c06436
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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