(S)-(+)-4-(2,3-Epoxypropoxy)carbazole → HCID 10277388, compound

HRID 1634796Notes

Reaction equation

HRID 1634796 reaction equation
[O:1]1[CH2:3][C@H:2]1[CH2:4][O:5][C:6]1[C:18]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]=2[CH:9]=[CH:8][CH:7]=1.NCC1CCN([NH:27][C:28](=[O:36])[NH:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]2)CC1>>[CH:30]1([NH:29][C:28]([N:27]2[CH2:7][CH2:6][CH:18]([CH2:10][NH:11][CH2:3][C@H:2]([OH:1])[CH2:4][O:5][C:6]3[C:18]4[C:17]5[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=5)[NH:11][C:10]=4[CH:9]=[CH:8][CH:7]=3)[CH2:17][CH2:16]2)=[O:36])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

3

Reactant 2

HCID 10879208(S)-(+)-4-(2,3-Epoxypropoxy)carbazoleHCID 18678573HCID 18678573, compound

Product 1

HCID 10277388HCID 10277388, compoundYield 0.1%

Procedure

Prepared from 4-[(2S)-oxiranylmethoxy]-9H-carbazole (0.175 g, 0.73 mmol) and 3-(4-aminomethyl-1-piperidinyl)-1-cyclohexyl urea (0.360 g, 1.5 mmol) according to the procedure used in example 2 to give 0.095 mg of the title compound as an off white solid.

Sources & evidence

ORD record
ord-544b5ac07b6644029fb46da4cce1647c
Source dataset
uspto-grants-2003_01
Patent number
US06506901B2

Reaction notes

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