HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzamide, 2,6-difluoro-N-methyl- → 1-(2,6-Difluorophenyl)-N-methylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzamide, 2,6-difluoro-N-methyl- | HCID 4106176 | — |
| Reactant | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(2,6-Difluorophenyl)-N-methylmethanamine | HCID 16790114 | 51% |
Reaction Steps
Prepared from 2,6-difluoro-N-methyl-benzamide (3.2 g, 18.7 mmol) and borane-methylsulfide (47 mL of a 2 M solution in toluene) according to the procedure used for example 84 (Step B) to give 1.5 g of the title compound which was used directly in the next prep.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06506901B2 |
| Source dataset | uspto-grants-2003_01 |
| ORD ID | ord-72b2b6556c0246ec9557aa545f1d2381 |
| Source note | uspto-grants-2003_01 |