2,5-Difluoro-N-(1-methylethyl)benzamide → HCID 18678623, compound

Participants

Reaction Steps

2,5-Difluoro-N-isopropyl-benzamide (0.5 g, 0.0025 mol) was dissolved in THF (8 mL). Lithium aluminum hydride (8 mL of a 1M solution in THF) was added, and the reaction was heated at reflux. When complete by TLC (methanol/methylene chloride), the reaction was cooled, and quenched with water, aqueous NaOH (15%), water and Na2SO4. The white solid is filtered off, and the filtrate is concentrated in vacuo to give 0.3 g of the amine. The product was used in the next step without characterization.

Provenance & Evidence